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| Id: | 18385
| | Author: | Consigny, Sophie; Bentoucha, Abdelhalim; Bonnafous, Pascale; Grosset, Jacques; Ji, Baohong
| | Title: | Bactericidal activities of HMR 3647, moxifloxacin, and rifapentine against Mycobacterium leprae in mice
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| | Source: | s.l; s.n; 2000. 3 p. tab.
| | Abstract: | Bactericidal activities of HMR 3647 (HMR), moxifloxacin (MXFX), and rifapentine (RPT) against Mycobacterium leprae, measured by the proportional bactericidal technique in the mouse footpad system, were compared with those of the established antileprosy drugs clarithromycin (CLARI), ofloxacin (OFLO), and rifampin (RMP. Administered in five daily doses of 100 mg/kg of body weight, HMR appeared slightly more bactericidal than CLARI. In a single dose, MXFX at 150 mg/kg was more active than the same dose of OFLO and displayed exactly the same level of activity as RMP at 10 mg/kg; the combination MXFX-minocycline (MINO) (MM) was more bactericidal than the combination OFLO-MINO (OM); RPT at 10mg/kg was more bactericidal than the same dose of RMP and even more active than the combination RMP-OFLO-MINO (ROM); the combination RPT-MXFX-MINO (PMM) killed 99.9% of viable M. leprae and was slighthy more bactericidal than RPT alone, indicating that the combination PMM showed an additive effect against M. leprae (AU).
| | Descriptors: | HANSENIASE/quimioter
HANSENOSTATICOS/admin
HANSENOSTATICOS/farmacol
HANSENOSTATICOS/farmacocin
HANSENOSTATICOS/uso terap
MYCOBACTERIUM LEPRAE
TESTES DE SENSIBILIDADE MICROBIANA/métodos
DROGAS EM INVESTIGACAO/admin
DROGAS EM INVESTIGACAO/anal
DROGAS EM INVESTIGACAO/uso terap
- BACTERICIDAS
QUIMIOTERAPIA COMBINADA
MYCOBACTERIUM LEPRAE/metab
MYCOBACTERIUM LEPRAE/fisiol
DAPSONA/uso terap
RIFAMPINA/uso terap
CLOFAZIMINA/uso terap
OFLOXACINO/uso terap
MINOCICLINA/uso terap
CLARITROMICINA/uso terap
| | Limits: | ESTUDO COMPARATIVO
| | Location: | BR191.1; 09311/s |
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